The Slayer's Take is a guild in Vasselheim that is paid to hunt rare animals, typically for specific parts of the animal. The Slayer's Take pays homage to Ioun, the goddess of knowledge, prophecy, and skill.
A large gynosphinx, Osysa, lives in a cavern below the guildhall. She uses her knowledge and scrying abilities to guide the Slayer's Take. The guild members are led by Vanessa Cyndrial, a no-nonsense tiefling. The second-in-command is her husband, Mertin Cyndrial, a halfling.
When Vox Machina wished to become members of the guild, they were first tested by being sent to complete a contract in under three days. Upon returning to the guildhall after successfully completing their contracts, Vox Machina were brought to meet the sphinx Osysa. Osysa branded each of their shoulders with the guild mark, identifying them as fully fledged members of the Slayer's Take.
- Vanessa Cyndrial (guildmaster)
- Mertin Cyndrial (second-in-command)
- Kashaw Vesh
- Thorbir Falbek
- Vox Machina (except Pike)
- Zahra Hydris
The members of Vox Machina (except Pike) were forced to join the Slayer's Take to avoid being prosecuted for poaching a hydra that was under contract by one of the guild's parties. In order to rectify the situation, Vox Machina was given the option to complete an initiation and join the guild, making the hydra kill legal. For the initiation, Vox Machina was split into two groups. One group was assigned a contract to hunt and kill a white dragon, Rimefang, in the Vesper Timberland, while the other group hunted a rakshasa, Hotis, in Vasselheim.